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我院135例药品不良反应报告分析

Analysis of 135 ADR Cases Reported in Our Hospital
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摘要 目的:解我院药品不良反应(ADR)发生的一般规律及特点,为临床合理用药提供参考。方法:收集我院2007~2009年向北京市药品不良反应监测中心上报的ADR报表135份,按患者性别、年龄、给药途径、药品种类、ADR累及的器官或系统及临床表现、严重ADR、ADR构成比排序居前10位的药品等方面进行统计、分析。结果:135例ADR报告中涉及的药品共14类46种,其中抗微生物药引发的ADR最多(占39.26%);静脉滴注是引发ADR的主要给药途径(占91.11%);皮肤及其附件损害最为常见(占48.15%);严重的ADR 4例(占2.96%)。结论:应重视ADR的报告和监测工作,以减少或避免ADR的发生,促进临床合理用药。 Objective : To study the general rules and characteristics of adverse drug reactions (ADR) occurring in our hospital so as to provide reference for rational clinical drug use. Method: A total of 135 ADR cases submitted to Beijing ADR Monitoring Center by our hospital via the network system from 2007 to 2009 were statistically analyzed in respect of patients' age and sex, routes of administration, drug categories, ADR-involved organs or systems, clinical manifestations, serious ADR, and top 10 drugs in terms of number of ADR cases, etc. Result: Of the 135 ADR cases, the number of drugs involved in totaled 14 categories and 46 kinds. The occurrences of ADR induced by antimicrobial drugs took the lead, accounting for 39.26%. The intravenous route was the chief ADR-inducing route, accounting for 91.11%. Lesions of skin and its appendants were the common ADR types, accounting for 48.15%. There were 4 severe cases (2.96%). Conclusion:Importance should be attached to the reporting and monitoring of ADR to lessen or avoid the occurrence of ADR and promote rational clinical use of drugs.
作者 尚丛笑
出处 《药物流行病学杂志》 CAS 2010年第11期627-629,共3页 Chinese Journal of Pharmacoepidemiology
关键词 药品不良反应 报告 分析 合理用药 Adverse drug reaction Report Rational drug use
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