我院老年CCU病区心肌能量代谢支持药物利用调查

Analysis of the Applications of the Myocardial Energy Metabolic Support Drugs in Our Elderly Cardiac Care Unit

目的:了解我院老年CCU病区心肌能量代谢支持药物的临床应用情况,促进其合理应用。方法:利用美康合理用药临床药学工作站,搜集并筛选2009年我院老CCU病区应用心肌能量代谢支持药物的住院患者共92例,采用Excel 2003对其性别、年龄、临床诊断、心肌能量代谢支持药物的种类、用法、用量、不良反应等情况进行统计分析。结果:92例患者中,用于心肌能量代谢支持治疗的药物主要有注射用磷酸肌酸钠、左卡尼汀注射液、盐酸曲美他嗪、辅酶Q_(10)、左卡尼汀口服溶液、注射用心肌肽,主要用于心肌梗死、心绞痛、心力衰竭等疾病,其中注射用磷酸肌酸钠、左卡尼汀注射液应用最为广泛,分别占用药总人数的95.65%、81.52%,其次为曲美他嗪(30.43%)。53.26%患者联合应用注射用磷酸肌酸钠和左卡尼汀注射液,个人单次剂量多为4 g,人均每日用药量分别为3.73 g和3.41 g,其中磷酸肌酸钠最高单次用药量达5 g。结论:我院心肌能量代谢支持药物已成为常规心血管治疗药物基础上不可或缺的辅助治疗药物,应用基本合理。但仍存在药物超剂量使用的问题,应严格掌握药物的用法、用量,促进心肌能量代谢支持药物合理应用。

Objective ： To analyze the clinical application of myocardial energy metabolic support drugs in our elderly cardiac care unit in order to promote the reasonable drug use. Method ：92 inpatients who were given myocardial energy metabolic support therapy in our elderly cardiac care unit from January 1 st 2009 to September 31 st 2009 were selected by Meikang clinical pharmacy workstation. And the data were statistically analyzed by Excel 2003 according to the age, clinical diagnosis, kind of drugs and so on. Result： Among the 92 elderly inpatients, myocardial energy metabolic support drugs including creatine phosphate sodium for injection, levocarnitine injection, trimetazidine hydrochloride, co-enzyme Q10, levocarnitine oral solution and cardiomyopeptide for injection were mainly used for myocardial infarction, angina, heart failure and so on. The proportions of inpatient using creatine phosphate sodium for injection and levocarnitine injection were 95.65% and 81.52% , respectively, which indicated that creatine phosphate sodium for injection and levocarnitine injection were mostly used in our hospital. And the next was trimetazidine hydrochloride used for 30.43% inpatients. 53.26% inpatients used creatine phosphate sodium for injection concomitant with levocarnitine injection. The drug consumption per person a day of creatine phosphate sodium for injection and levocarnitine injection was 3.73 g and 3.41 g, respectively, and their common individual single dose was 4 g while the maximal individual single dose of creatine phosphate sodium for injection was up to 5 g. Conclusion：In our hospital, myocardial energy metabolic support drugs have become an indispen- sable adjunctive treatment of inpatients in the elderly cardiac care unit based on the routine cardiovascular medicine. Their application was relatively reasonable. But there were some mistaken applications yet. Only through adhering to the principle of effective, safe, economical and rational drugs use and strictly controlling the usage and dose of drugs can a reasonable application of myocardial energy metabolic support drugs be achieved.