雌激素对急性酒精灌胃后小鼠胃粘膜损伤的保护作用

Protective effect and mechanism of estrogens on experimental gastric mucosal lesion in mice

目的:探讨雌激素对急性酒精灌胃后小鼠胃粘膜损伤的保护作用。方法:将50只雄性小鼠随机平均分为生理盐水对照组、雌激素对照组、模型组、模型+低剂量雌激素组和模型+高剂量雌激素组。模型组用酒精灌胃制作急性酒精性胃粘膜损伤动物模型。处理结束后计算各组溃疡指数及测定其胃粘膜组织中丙二醛(MDA)和超氧化物歧化酶(SOD)含量。结果:胃溃疡模型组血清中SOD活性降低,MOD含量增加,溃疡指数明显增加;低剂量和高剂量雌激素组血清中SOD活性提高,MOD含量降低,溃疡指数较模型组明显降低,各组数据与模型组相比差异有显著性。结论:雌激素对急性酒精灌胃致胃粘膜损伤有一定的保护作用。

Objective： To observe the protective effect and mechanism of estrogens on experimental gastric mucosal lesion in mice.Methods：The acute gastric ulcer was induced by intragastrical ethano1.The ulcer tissues of stomach were collected to examine ulcer size,ulcer inhibition rate and ulcer index.Meanwhile,the levels of SOD and MDA in ulcer tissues were also measured.Results：In the acute gastric ulcer model group,significantly protective effect was observed in the groups treated with estrogens in both high and low dosage.The size of ulcer and the ulcer index in the estrogens high and low dosage group decreased more remarkably than that of acute gastric ulcer model group.The mechanisms underlying anti-gastric ulcer effects of estrogens involved reduction in the MDA levels and increased in SOD levels in the gastric mucus.Conclusion： Estrogens protect the gastric mucosa,and the mechanism of which may correlate with antioxidation.