期刊文献+

ACEI类药物治疗IgA肾病疗效的Meta分析 被引量:3

下载PDF
导出
摘要 目的评价ACEI类药物治疗IgA肾病的有效性及安全性,为临床合理使用该类药物提供依据。方法采用meta分析方法,根据选择标准收集文献,应用RevMan4.2软件计算加权均数差(WMD)及其95%的可信区间。结果 ACEI类药物能够有效减少尿蛋白,降低收缩压和舒张压、WMD及其95%CI分别为-0.71(-0.9,-0.51)、-5.13(-6.53,-3.74)以及-5.16(-6.23,-4.10),对血肌酐水平并无明显影响,WMD及其95%CI为-0.10(-0.24,0.03)。结论 ACEI类药物能够有效治疗IgA肾病,且较为安全。
出处 《中国卫生统计》 CSCD 北大核心 2010年第5期510-511,共2页 Chinese Journal of Health Statistics
基金 南通市重大科技创新专项(XA2009001-6)
  • 相关文献

参考文献6

二级参考文献11

  • 1刘建平,夏芸.中文期刊发表的中医药系统综述或Meta-分析文章的质量评价[J].中国中西医结合杂志,2007,27(4):306-311. 被引量:59
  • 2Donadio J V, Grande J P. IgA nephropathy. N Engl J Med, 2002,34: 738 ~ 748
  • 3Coppo R, Amore A, Gianoglio B, et al. Angiotensin Ⅱ local hyperreactivity in the progression of IgA nephropathy. Am J Kidney Dis, 1993,21:593~602
  • 4Del Prete D, Gambaro G, Lupo A, et al. Precocious activation of genes of the renin-angiotensin system and the fibrogenic cascade in IgA glomerulonephritis. Kidney Int,2003,64:149~159
  • 5Lai K N, Tang S C, Guh J Y, et al. Polymeric IgAl from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesAngial cells via the renin-angiotensin system. J Am Soc Nephrol, 2003,14:3127~3137
  • 6Lai K N, Chan L Y, Tang S C, et al. Mesangial expression of angiotensin Ⅱ receptor in IgA nephropathy and its regulation by polymeric IgA1. Kidney Int,2004,66:1403~1416
  • 7Largo R, Gomez-Garre D, Soto K, et al. Angiotensinconverting enzyme is upregulated in the proximal tubules of rats with intense proteinuria. Hypertension, 1999,33: 732 ~ 739
  • 8Chan L Y, Leung J C, Lai K N. Novel mechanisms of tubulointerstitial injury in IgA nephropathy: a new therapeutic paradigm in the prevention of progressive renal failure. Clin Exp Nephrol, 2004,8:297~ 303
  • 9Chan L Y, Leung J C, Tsang A W, et al. Activation of tubular epithelial cells by mesangial-derived TNF-alpha:glomerulotubular communication in IgA nephropathy.Kidney Int,2005,67: 602~612
  • 10Campbell R, Sangalli F, Perticucci E, et al. Effects of combined ACE inhibitor and angiotensin Ⅱ antagonist treatment in human chronic nephropathies. Kidney Int,2003,63:1094~1103

共引文献27

同被引文献19

引证文献3

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部