痰湿证睡眠呼吸暂停患者CPAP压力水平研究

The Research on Proper CPAP Pressure Level of OSA Patients'with Phlegm Damp Syndrome

目的:对痰湿证睡眠呼吸暂停(OSA)患者运用持续正压通气(CPAP)治疗,探讨呼吸机压力水平和BMI、颈围、最低血氧、AHI、鼾声指数的关系,推导相关压力值计算公式,方便临床应用。方法:对54例痰湿证OSA患者行呼吸机压力滴定,分析呼吸机压力水平和BMI、颈围、最低血氧、AHI、鼾声指数的相关性,得出平均压力的多元线性回归方程,用于临床参考。结果:(1)CPAP治疗前后AHI指数和鼾声指数有显著差异(P<0.01),CPAP治疗疗效显著。(2)BMI、颈围、最低血氧、AHI、鼾声指数均和平均压力直线相关(P<0.01)。(3)根据多元线性逐步回归,得出平均压力=0.220×颈围+0.036×AHI+0.001×鼾声指数-3.746。结论:OSA患者BMI、颈围、最低血氧、AHI、鼾声指数均与CPAP平均压力显著相关,通过回归方程计算得出相关压力水平。

Objective：To treat the OSA patients of Phlegm damp syndrome with continuous positive airway pressure,discuss the relation between CPAP pressure and BMI,neck circumference,the lowest oxygen,AHI and snore index,form a multivariate linear regression equation about average pressure,which can be used in the clinic practice. Methods：To treat OSA patients of Phlegm damp syndrome with continuous positive airway pressure,and form a multivariate linear regression equation which can be used to calculate the average pressure with related data. Results：（ 1） There is significant difference between AHI and the snore index before and after the treatment of continuous airway pressure（ P 0. 01） ,The effect of this treatment is significant. （ 2） BMI,neck circumference,the lowest oxygen,AHI and snore index are correlated to average pressure（ P 0. 01）. （ 3） According to multivariate linear regression equation,we found the multivariate linear regression equation is as follows：average pressure of CPAP = 0. 220 ？？neck circumference ＋ 0. 036 ？？AHI ＋ 0. 001 ？？snore index -3. 746. Conclusion：BMI,neck circumference,the lowest oxygen,and snore index significant correlate to average pressure; we can get the pressure level by the multivariate linear regression equation.