Livin基因一肿瘤治疗新靶点

Livin gene--new target for cancer therapy

Livin是凋亡抑制蛋白（IAPs）家族的新的重要成员。Livin在多种肿瘤细胞中高表达，参与抑制细胞凋亡，与肿瘤发生发展密切相关。研究发现，通过下调或抑制Livin基因的表达及诱导产生特异性地识别Livin的抗体可抑制、杀死肿瘤细胞，为恶性肿瘤的诊断、细胞和基因靶向治疗等提供新的方法。

Livin is a new and important member of the inhibitor of apoptosis protein（IAPs） family. Livin is high expressed in most human tumor cells, involved in apoptosis inhibition and closely related with tumor development and progression. Studies found that through the down-regulation or inhibition of Livin expression and the induction specific antibodies of Livin could inhibi and kill tumor cells, which provided a new method for tumors＇ diagnosis, cell and gene targeted therapy.