呼吸系统真菌感染的耐药分析

Drug Resistance Analysis of Fungus Infection in Respiratory System

目的了解呼吸系统真菌感染的发生率与耐药率,为其防治提供依据。方法调查并分析2007～2009年我院呼吸内科住院患者956例痰培养与药敏试验结果。结果 2007～2009年真菌感染例数分别为52例、69例、77例。其中白色念珠菌110例,占55.6%。2007～2009年白色念珠菌对伊曲康唑(0、0、5.1%)、两性霉素B(0、0、2.8%)、制霉菌素(0、0、3.0%)的耐药率相对较低,光滑念珠菌对两性霉素B(0、0、20.0%)、制霉菌素(0、0、19.0%)的耐药率相对较低。结论呼吸科住院患者真菌感染的发生率与耐药率逐年增加,白色念珠菌为深部真菌感染的主要菌种。

Objective To investigate the incidence of respiratory fungal infection and drug resistance in an attempt to provide essential basis for preventing and treating it. Methods The investigation and analysis of the results of 956 cases of sputum culture and drug sensitivity in our hospital from 2007 to 2009 were carried out. Results There were 52,69 and 77 cases of fungal infection, respectively,from 2007 to 2009,of which 110 cases were candida albicans, accounting for 55.6%. From 2007 to 2009,the resistance rates of candida albicans to itraconazole（0,0,5.1%）,to amphotericin B（0,0,2.8%） and to nystatin（0,0,3.0%） were relatively lower, and the resistance rates of candida glabrata to amphoteriein B （0,0,20.0%） and to nystatin （0,0,19.0%） were relatively lower. Conclusion The incidence of respiratory fungal infection and the drug resistance rate in the respiratory hospitalized patients increase year by year. Candida albicans is the major fungal infection bacteria.