摘要
介绍肿瘤治疗新靶标Hsp90的作用机制,阐述格尔德霉素(geldanamycin,GM)对Hsp90的抑制作用,简述GM及其衍生物的抗肿瘤研究进展,对处于临床试验中的GM衍生物进行归纳。
The mechanism of Hsp90 as a cancer therapeutic target was introduced. How the GM inhibit the Hsp90 was reviewed. The current status of novel research progress of anti-tumor activities of GM and its derivation was briefly introduced. The drugs of the derivation of GM in the clinical status were summarized.
出处
《国外医药（抗生素分册）》
CAS
2010年第5期202-206,共5页
World Notes on Antibiotics
