大连市自然人群乙肝血清流行病学调查结果分析

Analysis of Epidemiological Satus Among Residents in Dalian

目的了解大连市自然人群乙肝(HBV)的流行现状及流行特征;评价乙肝疫苗纳入儿童计划免疫策略后的防制效果,为政府部门进一步制定乙肝的防制措施提供科学依据。方法采用分层随机抽样法,在全市11个县市区按照0～、1～、2～、5～、10～和15～岁6个年龄段,共采集血清标本680份,按《WS299-2008乙型病毒性肝炎诊断标准及处理原则》,采用酶联免疫吸附实验(ELISA法),检测血清中HBsAg、抗-HBs、抗-HBc、HBeAg和抗-HBe五项指标。结果 HBsAg携带率为7.11%,抗-HBs阳性率为58.82%,抗-HBc、HBeAg、抗-HBe阳性率分别为24.56%、0.15%和2.94%。结论从年龄来看,全人群HBsAg携带率为1.18%,<5岁人群HBsAg携带率为0.59%,已完成《2006-2010年全国乙型病毒性肝炎防治规划》目标要求,乙肝疫苗纳入国家免疫规划效果显著。

Objective To analyze epidemiological satus and characteristics of HBV among residents in Dalian.To evaluate the effect of Hepatitis B vaccines added to national children immunization program,so as to provide scientific basis for the government to make measures to prevent Hepatitis B further.Methods Using stratified random sampling method,in the 11 districts,a total of 680 serum samples were collected and devided into six age groups（0～,1～,2～,5～,10～and15～） according to《WS299-2008 Hepatitis B diagnostic criteria and treatment principles》.By Enzyme-Linked Immunosorbent Assay（ELISA）,HBsAg,anti-HBs,anti-HBc,HBeAg and anti-HBe were detected.Results The carrier rates of HBsAg,anti-HBs,anti-HBc,HBeAg and anti-HBe were 7.11%,58.82%,24.56%,0.15%and 2.94%.Conclusion The carrier rate of HBsAg in whole population was 1.18%,and the carrier rate of HBsAg in 5-years-old was 0.59%,which has completed the objectives of《2006-2010 Hepatitis B prevention and control planning》.The results of bringing hepatitis B vaccine into national immunization program are obvious.