大肠癌单克隆抗体在大肠癌诊断中的临床价值

Clinical Value of Colorectal Carcinoma Monoclonal Antibody in Diagnosis of Colorectal Carcinoma

为了探讨大肠癌单克隆抗体（ＭＡ）在大肠癌诊断中的意义，本文采用大肠癌ＭＡ金标免疫斑点法对２６例大肠癌患者粪便检测肿瘤相关抗原，并与血清中癌胚抗原（ＣＥＡ）测定进行比较，同时与１５例良性肠道疾病对照，结果显示：大肠癌ＭＡ金标免疫斑点法阳性率８４６％，ＣＥＡ阳性率３８５％，对照组１３３％，差异有显著性。

The diagnostic value of colorectal carcinoma monoclonal antibody(MA) was explored,the tumor associated antigen in stool specimens of 26 patients with colorectal carcinoma were detected by using dotty immunoassay with colorectal carcinoma gold labelled MA,in the meanwhile,also measured carcinoma embryo antigen(CEA) in serum (CEA group),and used 15 patients with beingn colorectal disease as a control group.The results showed that the positive rate of tumor associated antigen in experimental group was 84 6%(22/26),but the positive rate of tumor associted antigen in control group was only 13 3% (2/15 cases).The positive rate of CEA in CEA group was 38 5% (10/26 cases).There was significant difference among the three groups.It suggests that the colorectal carcinoma MA gold labelled dotty immunoassay in screening and early diagnosis of colorectal carcinoma has an important clinical value.