一种简易的小鼠帕金森氏病模型的建立

A Convenience Model of Parkinson's Disease in Mice

小鼠i．p．氟哌啶醇2mg/kg后，出现僵住症，东莨胆硷可拮抗。i.p.20mg/kg后出现震颤、行动过缓、强直。上述表现是帕金森氏病的典型症状。实验结果表明，用氟哌啶醇制作帕金森氏病模型是简易可靠的。

i.p. haloperidol (Hal) Ztwkg in face, the catalepsy was induced, and which antagonized by scolXildrine. After 20mg/kg, inducing the threll, twist and tetanus, The characteristics at mention were the classicedinson's disease. The resultS indicated that the Inodel of Parkinson's disease induced by Hal was credible and successful.