利用激光固化技术制作硬骨骼支架模型

Fabrication of hard bone scaffold molds using selective laser curing technology

为了使用选择性激光固化技术制作出符合生物兼容性与多孔性之硬骨骼支架,利用医用陶瓷浆料具有的黏度支撑效果,制作多孔性的骨骼支架模型;以扫描电子显微镜观察支架固化、激光烧结以及高温处理后的微观组织结构,利用原子力显微镜量测出表面粗糙度。结果表明,医用陶瓷浆料所具有的黏度使支架容易成型,使用CO_2激光烧结后之微观结构呈固熔化状,经过高温处理后可提高支架之致密性,使其表面粗糙度有增大的趋势,有利于类骨母细胞之附着及成长。

In order to fabricate a porous hard bone scaffold mold with biological compatibility, it was made of hydroxyapatite based bioceramic because of the viscosity and support effect of bioceramic slurry. Then the microstructure of the solidified scaffolds after laser sintering and high-temperature post-process was observed with a scanning electron microscope. Furthermore, the surface roughness was measured with an atomic force microscope. The results show that the density and the surface finish of scaffolds can be increased after post process, which is good for the attachment and growth of osteoblast-like cells.