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CD147、MMP-1、MMP-2、MMP-9、TIMP-1、TIMP-2在不同级别的脑胶质瘤中的表达及其意义 被引量：5

Expressions of CD147,MMP-1,MMP-2,MMP-9,TIMP-1,TIMP-2 in different grades gliomas patients
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摘要 目的探讨CD147、MMP-1、MMP-2、MMP-9、TIMP-1、TIMP-2在胶质瘤中的表达及其相关性,方法采用免疫组织化学法对78例石蜡包埋的胶质瘤组织和12例正常脑组织进行标记和分析。结果CD147、MMP-1、MMP-2、MMP-9、TIMP-1、TIMP-2的阳性率分别为62%、66%、64%、75%、59%、59%,采用Spearm an进行相关性分析,他们与胶质瘤的恶性程度均呈正相关（rs=0.2671-0.5631,P〈0.05）,CD147与MMP-1、MMP-2和MMP-9呈正相关（rs=0.3481-0.4951,P〈0.05）。结论CD147、MMPS、TIMPs可以作为临床判断胶质瘤预后的分子生物学标志。 Objective：To investigate the expressions of CD147,MMP-1,MMP-2,MMP-9,TIMP-1 and TIMP-2 in human gliomas and to study their correlation.Methods： The expressions of CD147,MMP-1,MMP-2,MMP-9,TIMP-1 and TIMP-2 were assessed in paraffin-embedded specimens collected from 78 cases of gliomas and 12 cases of benign brain tissue by immunohistochemistry.Results： Their expressons were 62%,66%,64%,75.%,59%,59%.Using Spearman analysis,a significant positive correlation between CD147,MMP-1,MMP-2,MMP-9,TIMP-1,TIMP-2 and gliomas expression was found（rs=0.2671～0.5631,P〈0.01）.The correlation was significant between CD147 and MMP-1,MMP-2,MMP-9（rs=0.3481～0.4951,P〈0.01）.Conclusion： The results suggest that concurrent expression of CD147 and MMPs may be an important characteristic of gliomas patients which may help in the prediction of gliomas progression.
作者 居红格 蒋剑英 沈淑萍 耿虹
机构地区 包头医学院病理学教研室
出处 《泰山医学院学报》 CAS 2010年第9期653-655,共3页 Journal of Taishan Medical College
基金 包头医药卫生基金项目(2009S1001-30)
关键词 CD147、MMP-1、MMP-2、MMP-9、TIMP-1、TIMP-2 胶质瘤 CD147 MMP-1 MMP-2 MMP-9 TIMP-1 TIMP-2 gliomas
分类号 R739.41 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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共引文献10

同被引文献38

  • 1夏鹤春,买正军,马泽,郝少才.MMP-2与TIMP-2在神经胶质瘤侵袭中的作用及其意义[J].宁夏医学杂志,2006,28(5):339-341. 被引量：4
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  • 10周任,柏鲁宁,王睿智,张龙洲,包新杰,曹杰.基质金属蛋白酶-2及其抑制因子TIMP-2在脑胶质瘤中的表达及意义[J].西安交通大学学报（医学版）,2008,29(6):686-688. 被引量：2

引证文献5

二级引证文献9

泰山医学院学报
2010年 第9期

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