阿莫西林联合叶酸对慢性萎缩性胃炎患者多项血清因子水平的影响

Effect of Amorim and Folic Acid on the Levels of Multiple Serum Factor in Patients with Chronic Atrophic Gastritis

目的:探讨阿莫西林联合叶酸对慢性萎缩性胃炎患者多项血清因子水平的影响。方法:选取2008年12月～2010年2月于我院进行治疗的80例慢性萎缩性胃炎患者,将其采用随机双盲法分为对照组40例和观察组40例,对照组采用叶酸治疗,观察组采用阿莫西林联合叶酸治疗,将2组患者的治疗效果、不良反应发生率和治疗前、后的血清表皮生长因子、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、胃蛋白酶原Ⅰ、胃泌素、分泌型免疫球蛋白-A(sIgA)水平进行统计检测及比较。结果:观察组的不良反应发生率与对照组比较,无显著性差异(P>0.05),而治疗总有效率高于对照组,血清表皮生长因子、IL-6、TNF-α、sIgA水平低于对照组,胃泌素、胃蛋白酶Ⅰ原高于对照组,均有显著性差异(P<0.05)。结论:阿莫西林联合叶酸对慢性萎缩性胃炎患者多项血清因子水平的影响较大,总有效率明显提高,值得临床进一步研究。

OBJECTIVE：To explore effect of amorim combined with folic acid on the levels of multiple serum factors in patients with chronic atrophic gastritis.METHODS：In double-blind randomized study,80 cases of chronic atrophic gastritis in our hospital during Dec.2008～Feb.2010 were divided into control group and observation group（40 cases）.Control group were treated with folic acid and observation group received folic acid and amorim.The therapeutic efficacy,the incidence of adverse reactions,serum epidermal growth factor before and after treatment,the levels of interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）,pepsinogen Ⅰ,gastrin,secretory immunoglobulin-A（sIgA）were detected statistically and compared.RESULTS：The incidence of adverse reactions had no significant difference between observation group and control group（P〈0.05）.The total effective rate,gastrin,pepsinogen Ⅰ of observation group was higher than control group while serum epidermal growth factor,the levels of IL-6,TNF-α,sIgA in observation group were lower than control group（all P〈0.05）.There were significantly different.CONCLUSION：Amorim combined with folic acid influence the levels of serum factors in patients with chronic atrophic gastritis significantly.The total effective rate increase significantly.It is worthy of further study.