辛伐他汀治疗心肌梗死的疗效观察

Observation of Comprehensive Effect of Simvastatin in the Treatment of Myocardial Infarction

目的:观察辛伐他汀在心肌梗死治疗中的疗效。方法:选取2008年1月～2009年5月于我院进行治疗的50例心肌梗死患者为研究对象,将其随机分为对照组与观察组,各25例。对照组采用常规方法进行治疗,观察组在对照组的基础上加用辛伐他汀进行治疗。治疗后对2组患者的心功能killp分级、1年存活率、心血管疾病再发生率及治疗前后的血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、心肌型肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、天冬氨酸氨基转移酶(AST)及心肌钙蛋白I(cTnI)水平进行检测及比较。结果:治疗后观察组的心功能killp分级情况优于对照组,1年存活率高于对照组,心血管疾病再发生率低于对照组;观察组血清hs-CRP、IL-6、CK-MB、LDH、AST和cTnI水平均低于对照组,2组比较差异均具有统计学意义(P<0.05或P<0.01)。结论:辛伐他汀在心肌梗死治疗中的综合效果明显,值得进一步研究。

OBJECTIVE：To study the comprehensive effect of simvastatin in the treatment of myocardial infarction.METHODS：50 MI patients in our hospital from Jan.2008 to May 2009 were selected as observation object,and they were randomly divided into control group and observation group（25 cases）.Both groups were given routine treatment and observation group were additionally treated with simvastatin.Then the killp grade,one year survival rate,reoccurrence rate of cardiovascular disease and the serum levels of hs-CRP,IL-6,CK-MB,LDH,AST and cTnI of 2 groups before and after treatment were detected and compared.RESULTS：The killp grade of observation group was better than that of control group,one year survival rate of observation group was higher than that of control group and reoccurrence rate of observation group was lower than that of control group.The serum levels of hs-CRP,IL-6,CK-MB,LDH,AST and cTnI of observation group were all lower than those of control group,there were significant differences（P〈0.05 or P〈0.01）.CONCLUSION：Simvastatin has significant comprehensive effect on MI,and it is worthy of further study.