二十五味松石丸治疗病毒性肝炎的随机对照临床研究

Randomized controlled clinical trial of ErshiwuweiSongshi Wan in the treatment of hepatitis B

目的研究二十五味松石丸(藏药验方)对病毒性肝炎的疗效。方法病毒性肝患者随机分为2组:试验组(n=310)与对照组(n=108例),分别口服二十五味松石丸(每次1 g,每日1次)与复肝宁片(每次0.25 g×6,每日3次),均3个月为1个疗程,评价2组的疗效、症状与体征及血生化指标等。结果治疗后,有效率:试验组与对照组分别为89%,68%;ALT恢复正常百分率:2组分别为64%,48%;总胆红素好转率:2组分别为71%,48%%;HbeAg阴转率:2组分别为29%,12%;上述指标2组比较均有显著性差异(P<0.05,P<0.01)。症状与体征改善,试验组与对照组比较也有统计学意义(P<0.01,P<0.05)。结论 2种药治疗病毒性肝炎均有显著疗效;但二十五味松石丸明显好于复肝宁片。

Objective To study the effective of ErshiwuweiSongshi Wan in the treatment of hepatitis B patients. Methods A randomized, controlled clinical study was carried out. In the study, 310 proper patients were enrolled in trial group （ ErshiwuweiSongshi Wan ） , 108 proper pa- tients were enrolled in control group （Fuganning tablets）. The daily dose of ErshiwuweiSongshi Wan and Fuganning tablets are 1 g once a day and 1.5 g 3 times a day, respectively. The treatment duration for both groups was 3 months. Results After treatment for trial and control groups, the effective rate was 89% ,68% , respectively;the negative response of ALT was 64% ,48% , respectively; the total improvement of total bilirubin was 71% ,48%, respectively; the negative response rate of HBeAg was 29% , 12% , respectively. There was significantly in two groups all above index （ P 〈 0.05 or P 〈 0.01 ）. The marked improvement of symptom and physical sign in two groups was significant also （ P 〈 0. 0. 5 or P 〈 0. 01 ）. Conelusion ErshiwuweiSongshi Wan is both effective and safe drug for hepatitis B . The efficacy of ErshiwuweiSongshi Wan better than Fuganning tablets.