摘要
目的:探讨血清Ⅰ型胶原吡啶交联终肽(ICTP)在类风湿关节炎(RA)中的临床意义。方法:对入选的86例RA患者、41例非RA患者及正常对照40例,采用酶联免疫吸附试验(ELISA)检测ICTP。结果:血清ICTP在RA组、非RA组中的浓度与正常对照组比较,均有显著性差异(P<0.05);与非RA组比较,RA组血清ICTP含量及阳性率均有统计学意义(均P<0.05)。结论:ICTP可作为RA患者关节损伤指标,对判断病情活动有重要意义。
Objective:To study the Clinical Application of Serum pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen(ICTP) Detection In Patients With Rheumatoid Arthritis(RA).Methods: Serum level of ICTP was measured by ELISA in 86 RA and 41 non-RA patients and 40 normal controls.Results: The serum levels of ICTP in the RA and non-RA patients were remarkably higher than that in the normal controls(P0.05);The serum level and positive rate of ICTP in the RA was remarkably higher than that in non-RA patients(P0.05).Conclusion: The serum level of ICTP can reflect the degree of joint destruction and the progression of the disease in patients with RA.
出处
《中国卫生检验杂志》
CAS
2010年第11期2913-2914,共2页
Chinese Journal of Health Laboratory Technology
关键词
Ⅰ型胶原吡啶交联终肽
关节炎
类风湿
临床应用
Pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰcollagen
Arthritis
Rheumatoid
Clinical application