类风湿关节炎患者血清Ⅰ型胶原吡啶交联终肽检测的临床应用

The clinical application of serum pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen detection In Patients with rheumatoid arthritis

目的:探讨血清Ⅰ型胶原吡啶交联终肽(ICTP)在类风湿关节炎(RA)中的临床意义。方法:对入选的86例RA患者、41例非RA患者及正常对照40例,采用酶联免疫吸附试验(ELISA)检测ICTP。结果:血清ICTP在RA组、非RA组中的浓度与正常对照组比较,均有显著性差异(P<0.05);与非RA组比较,RA组血清ICTP含量及阳性率均有统计学意义(均P<0.05)。结论:ICTP可作为RA患者关节损伤指标,对判断病情活动有重要意义。

Objective：To study the Clinical Application of Serum pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen（ICTP） Detection In Patients With Rheumatoid Arthritis（RA）.Methods： Serum level of ICTP was measured by ELISA in 86 RA and 41 non-RA patients and 40 normal controls.Results： The serum levels of ICTP in the RA and non-RA patients were remarkably higher than that in the normal controls（P0.05）;The serum level and positive rate of ICTP in the RA was remarkably higher than that in non-RA patients（P0.05）.Conclusion： The serum level of ICTP can reflect the degree of joint destruction and the progression of the disease in patients with RA.