弹性酶与脂必妥对糖尿病高脂血症及微量蛋白尿的疗效观察

Curative observations of elasatase and zhinbiticose on hyperlipidemia and microproteinuria of diabetes mellitus

目的：探讨弹性酶与脂必妥对糖尿病高脂血症及对早期糖尿病肾病的疗效。方法：８４例非胰岛素依赖型糖尿病患者随机分为弹性酶组和脂必妥组，比较２种药物对糖尿病高脂血症及微量蛋白尿的治疗效果。结果：总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬＣ）在弹性酶组治疗６周末分别下降了１０％、１９％和上升了８％（Ｐ均＜０．０１）；脂必妥组６周末分别下降了１１％、１６％和上升了７％（Ｐ均＜０．０１）。尿蛋白排泄率在脂必妥组平均上升了２．４％（Ｐ＞０．０５），弹性酶组平均下降了２５．７％（Ｐ＜０．０１）。结论：弹性酶与脂必妥对糖尿病高脂血症均有非常显著的疗效，而对尿蛋白排泄率（ＵＡＥＲ）的影响弹性酶优于脂必妥。

Objective :To observe the curative effects of elasatase and zhinbiticose on hyperlipidemia and early diabetic nephropathy. Methods :84 cases with non insulin dependent diabetes mellitus were randomly divided into elasatase group and zhinbiticose group.The comparison of curative effects on hyperlipidemia and microproteinuria of diabetes between two groups was carried out. Results :In elasatase group by the end of 6 months during therapy the total cholesterol (TC) and triglyceride (TG) were decreased 10% and 19% but high density lipoprotein cholesterol (HDL C) were increased 8% (all P<001),otherwise in zhinbiticose group those were 11%,16%,and 7% respectively (all P<001).The excretion rate of urinary protein in zhinbiticose group was elevated 24% (P>005) on average but in elasatase group was depressed 257% (P<001). Conclusions :Elasatase and zhinbiticose possess very obviously curative effects on hyperlipidemia of diabetes mellitus.The influence of elasatase on excretion rate of urinary protein was superior to that of zhinbiticose.