醒脑静注射液对急性脑梗死患者单核细胞CD_(54)^+分子表达的影响

Influence of Xingnaojing Injection on CD54 molecular expression in patients with acute cerebral infarctions

目的：探讨醒脑静注射液对急性脑梗死炎症反应的影响。方法：４０例急性期脑梗死患者，随机分为２组。对照组２０例用常规方法治疗；醒脑静组２０例在常规方法治疗的基础上加用醒脑静注射液治疗。观察患者病程第３、１０、１５日外周血单核细胞（ＰＢＭＣ）ＣＤ５４分子表达情况，并与２０例健康组作比较，同时观察临床疗效。结果：患者第３日ＰＢＭＣＣＤ＋５４分子处于高水平表达状态（与健康组比较，Ｐ＜０．００１）；第１０日时，醒脑静组降至健康组水平（Ｐ＞０．０５），而对照组仍显著高于健康组（Ｐ＜０．００１），至第１５日时才达健康组水平（Ｐ＞０．０５）；且醒脑静组愈显率６５．０％，显著高于对照组３０．０％（χ２＝４．９１，Ｐ＜０．０５）。结论：醒脑静注射液对急性脑梗死炎症反应具有抑制作用，治疗脑梗死患者有效。

Objective :To investigate the influence of Xingnaojing Injection(XNJI) on inflammatory reactions of acute cerebral infarctions. Methods :40 cases of acute phase were selected and randomly divided into two groups.The control group (n=20) was treated with conventional methods otherwise the treatment group treated with the same methods adding XNJI.The conditions of CD54 molecular expression of mononuclear cells in peripheral blood during the ill course on the 3th ,10th and 15th day were observed and compared with healthy subjects (n=20) and meantime the curative effects were abserved too. Results :On the 3th day the CD+54 molecules of mononuclear cells were in a high expression level and in comparison with healthy subjects the difference was significant (P<0001).On the 10th day in XNJI group they were depressed to the same level as that in healthy group (P>005),but in control group they were significantly higher than that in healthy group (P<0001) and till the 15th day they were reached to the level of healthy group (P>005).The markedly effective rate (650%) in XNJI group was significantly higher than that (300%) in control group (2=491,P<005). Conclusions :XNJI possesses inhibiting actions on inflammatory reactions of cerebral infarctions and is able to treat cerebral infarctions effectively.