腹部大手术术后深部真菌感染的临床与真菌学分析

Clinical and mycological analysis of deep fungal infection after general surgery

目的探讨腹部大手术术后深部真菌感染的危险因素及诊治措施。方法回顾性分析2006年1月～2009年6月期间我科腹部大手术术后合并深部真菌感染48例患者的临床和真菌学资料。结果 48例真菌感染患者共分离出56株菌株,其中白念珠菌占41.1%,是最主要的致病菌株。患者基础疾病和术后长期、多种广谱抗生素联合使用是深部真菌感染的重要因素。结论深部真菌感染是腹部大手术术后的重要并发症,白念珠菌仍然是主要病原菌。对术后患者深部真菌感染应采取积极预防、及时发现和有效治疗。

Objective To investigate the risk factors and prevention methods of deep fungal infection after general surgery.Methods The clinical and mycological materials of 48 cases with deep fungal infection after general surgery from 2006 to 2009 were retrospectively analyzed.Results Fifty-six strains were isolated from different specimens of the 48 patients.Candida albicans was the most frequently isolated pathogen,which accounted for 41.1%.Long-term and combination usage of broad-spectrum antibiotic,and underline disease were the risks factor for fungal infection.Conclusions The deep fungal infection is not uncommon and a severe complication after general surgery.Candida albicans was still the most frequently isolated pathogen.Appropriate use of antibiotics,timely mycological test and early diagnosis and treat in time were important for fungal infection.