慢性丙型肝炎的中西医治疗

Integrated traditional Chinese and western medicine therapy for chronic hepatitis C

慢性丙型肝炎的西医治疗以干扰素联合利巴韦林的抗病毒治疗为基础。对标准治疗无持续病毒学应答的难治性丙型肝炎,蛋白酶抑制剂等特异性靶向抗病毒治疗有助于HCV的清除,多药联合同时可能加重某些不良反应如皮疹、贫血等,影响治疗的依从性。中西医结合治疗在减轻丙型肝炎抗病毒药物不良反应如发热、肌肉酸痛、抑郁、贫血及白细胞下降等,改善患者对治疗的依从性,提高持续性病毒学应答,减少停药后的复发及保肝抗炎、抗肝纤维化等方面显现一些优势。

The standard treatment of chronic hepatitis C is interferon and ribavirin combination therapy. Specifically targeted antiviral therapies, such as the use of protease inhibitors, are helpful to eliminate HCV in the patients who have failed to achieve sustained virologic response （SVR） with the standard treatment. Drug combination may enhance some adverse reactions such as rash and anemia, and affect the treatment compliance. Integrated treatment of traditional Chinese medicine and western medicine shows some advantages in alleviating adverse reactions of antiviral therapy such as fever, muscular soreness, depression, anemia and aleu- cocytosis, improving treatment compliance and SVR rate, reducing relapse after drug withdrawal as well as achieving hepatoprotec- tion, anti-inflammation and anti-fibrosis.