摘要
目的:探讨转化生长因子-β1(TGF-β1)在肾细胞癌中的表达部位和程度以及与临床指标间的关系。方法:应用抗TGF-β1多克隆抗体对43例肾细胞癌进行免疫组化研究(同时取10例尸检正常肾组织作为对照)。结果:TGF-β1在肾癌组织中表达阳性率86.1%(37/43),明显高于正常肾组织(P<0.005);表达强度与术中见有无周围组织侵袭有相关性(P<0.05),与肿瘤大小无关。结论:TGF-β1表达是肾癌的恶性表型之一,对评估肾癌的预后有重要意义。
Objective:In this study,we studied the expression of TGF-1 in renal cell carcinoma and the relationship with the associated clinical data.Methods:Immunohistochemistry was used with anti-TGF-1 Multi-Ab to inspect the expression of TGF-1 in 43 cases of renal cell carcinoma and 10 cases of normal renal tissues as contrast.Results:The positive rate of TGF-1 expression in renal celll carcinoma was 86.1% (37/43 cases),and it was obviously higher than that in normal renal tissues (P<0005);the intensity of TGF-1 expression in renal cell carcinoma was related to the invasiveness of patients tumour tissues (P<005) and was not related to the tumors size (P>005).Conclusion:The above results suggest that the expression of TGF-1 is one of the malignant phenotypes in renal cell carcinoma and has remarkable significance in evaluating the prognosis of renal cell carcinoma.
出处
《白求恩医科大学学报》
CSCD
1999年第3期235-237,共3页
Journal of Norman Bethune University of Medical Science