摘要
Background A pulmonary-infected patient had severe hyponatremia that lasted two days during hospitalization.We could not find any history such as gluttony,liver and gall disease.The examination of liver function reported that the hepatic enzymology is normal.In ICU,we quickly found hemodiastase reached at extremely high level.The berry CT indicated that the head of pancreas swelling and the boundary was obscure and effusive.The patient was diagnosed as acute pancreatitis.This case raises a question to us：Does severe hyponatremia cause acute pancreatitis？ It has not been reported.Methods We established acute animal model of hyponatremia that did not include any other electrolyte chaos.After the animal model of hyponatraemia completed,serum amylase levels and pathological examination were analyzed.Results The hyponatremia models,out of 16 rats,only four rats＇ serum sodium were less than 120 mmol /L.In these four rats,besides serum sodium,the remaining electrolytes were normal and serum lipids were in normal range,only one rat＇s serum amylase increased significantly more than four times of the normal control group and its pathological findings hinted pancreatic edema.Conclusions The experimental model successfully duplicated the clinical and pathologic features of pancreatitis induced by hyponatraemia.Through this case report,we hope that attention can be paid to changes in serum amylase when hyponatremia appeared.
Background A pulmonary-infected patient had severe hyponatremia that lasted two days during hospitalization.We could not find any history such as gluttony,liver and gall disease.The examination of liver function reported that the hepatic enzymology is normal.In ICU,we quickly found hemodiastase reached at extremely high level.The berry CT indicated that the head of pancreas swelling and the boundary was obscure and effusive.The patient was diagnosed as acute pancreatitis.This case raises a question to us：Does severe hyponatremia cause acute pancreatitis？ It has not been reported.Methods We established acute animal model of hyponatremia that did not include any other electrolyte chaos.After the animal model of hyponatraemia completed,serum amylase levels and pathological examination were analyzed.Results The hyponatremia models,out of 16 rats,only four rats＇ serum sodium were less than 120 mmol /L.In these four rats,besides serum sodium,the remaining electrolytes were normal and serum lipids were in normal range,only one rat＇s serum amylase increased significantly more than four times of the normal control group and its pathological findings hinted pancreatic edema.Conclusions The experimental model successfully duplicated the clinical and pathologic features of pancreatitis induced by hyponatraemia.Through this case report,we hope that attention can be paid to changes in serum amylase when hyponatremia appeared.
