血清前白蛋白检测在肝病及其治疗过程中的应用

Clinincal Significance of Determining Serum Prealbumin in Patients with Viral Hepatitis

目的探讨检测肝病患者血清前白蛋白的临床应用价值。方法对149例肝病患者同时测定血清前白蛋白(PAB)、总蛋白、白蛋白,并对115例肝病患者治疗前后的血清前白蛋白进行动态观察。结果各肝病组血清前白蛋白水平显著低于健康对照组(P<0.01),急性肝炎组79.5%的病例PAB水平下降,而仅9.7%的病例白蛋白下降,两者比较差异有统计学意义(P<0.01)。各肝病组治疗后1个月与治疗前相比,血清PAB水平明显升高(P<0.01或P<0.05)。结论血清PAB较常规肝功能指标中的总蛋白、白蛋白能更灵敏、快速地反映肝病患者肝脏功能的损害程度,并有助于肝病的疗效观察。

Objective To investigate the clinical significance of determing serum prealbumin in patients with viral hepatitis. Methods The levels of prealbumin,albumin and total protein in 149 patients suffering from hepatic disease,were determined and analysed,besides serum preabumin was observed in 115 cases of viral hepatitis before and after clinical treatment. Results The levels of prealbumin were much more lower in the patient group compared with normal group（ P 0. 01） . In the acute hepatitis group,prealbumin dropped in 79. 5% cases,while albumin dropped only in 9. 7% cases,there was also significant difference between them（ P 0. 01） . There was also significal difference in leveles of prealbumin in the hepatic patients before treatment and one month after clinical treatment（ P 0. 01 or P 0. 05） . Conclusions Comparing with albumin and total protein,PAB is a more specific and sensitive parameter in evaluation of hepatic function than others,meanwhile it is helpful for prognsis.