1Semenza GL. A nuclear factor included by hypoxia viade novo protein synthesis binds to the human an erythropoietin gene enhancer at a site required for transeriptional activation [ J ]. Mol Cell Biol, 1992,12 ( 12 ) : 5447 - 5454.
2Semenza G L, Agani F, Booth G, et al. Structural and funetional analysis of hypoxia inducible factor[ J ]. Kidney Int, 1997,51 (2) :553 "555.
3Leyland - Jones B. Evidence for erythropoietin as a molecular targeting agent [ J ]. Semin Oncol, 2002,29 ( 3 Suppl 11) :145 - 154.
5Zhong H,Angelo M,Laughner D,et al. Over expression of hypoxia inducible factor - 1 α in common human cancers and their metastasis [ J ]. Cancer Res, 1999,8 (59) : 5830 - 5839.
6Kunz M, Ibrahim SM. Molecular responses to hypoxia in tumor cells[J]. Mol Cancer,2003,2( 1 ) :23.
7Duffy JP, Eibl G, Reber HA, et al. Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer [ J]. Mol Cancer,2003,2 : 12.
8Griffiths JR, Mcsheehy PM, Robinson SP, et al. Metabolic changes detected by in vivo magnetic resonance studies of HEPA- 1 wild- type tumors and tumors deficient in hypoxia - inducible factor - 1 beta ( HIF - 1 beta ) : evidence of an anabolic role for the HIF - 1 pathway [ J ]. Cancer Res. 2002,62( 3 ) :688 - 695.
9Semenza GL. Targeting HIF - 1 for cancer therapy [ J ]. Nat Rev Cancer,2003,3(10) :721 -732.
10Acs G, Zhang PJ, McGrath CM, et al. Hypoxia- inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine ervix and its potential role in cervical carcinogenesis and tumor progression [ J ]. Am J Patho1,2003,162 (6) : 1789 - 1806.
二级参考文献26
1Goda N, Ryan HE, Khadivi B, et al. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia[J]. Mol Cell Biol, 2003, 23(1): 359-369.
2Volm M, Koomagi R. Hypoxia-inducible factor ( HIF-1 ) and its relationship to apoptosis and proliferation in lung cancer[J]. Anticancer Res, 2000, 20(3A): 1527-1533.
3Bruick RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia [ J ]. Proc Natl Acad Sci U S A,2000, 97( 16): 9082-9087.
4Sowter HM, Ratcliffe PJ, Watson P, et al. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors[J]. Cancer Res, 2001, 61 (18): 6669-6673.
5Mabjeesh NJ, Post DE, Willard MT, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells[ J]. Cancer Res, 2002,62(9): 2478-2482.
6Kunz M, Ibrahim SM. Molecular responses to hypoxia in tumor cells[J]. Mol Cancer, 2003, 2(1): 23.
7Yeo EJ, Chun YS, Cho YS, et al. YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1 [ J ]. J Natl Cancer Inst,2003, 95(7): 516-525.
8Sun X, Kanwar JR, Leung E, et al. Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy[J]. Gene Ther, 2001, 8 (8): 638-645.
9Krishnamachary B, Berg-Dixon S, Kelly B, et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1 [ J ].Cancer Res, 2003, 63(5): 1138-1143.
10Hanze J, Eul BG, Savai R, et al. RNA interference for HIF-lalpha inhibits its downstream signalling and affects cellular proliferation[J]. Biochem Biophys Res Commun, 2003, 312(3): 571-577.
