非典型抗精神病药合并牛黄宁宫片致白细胞减少症的药物流行病学调查

Pharmacoepidemiological Survey of the Risk on Leucocytopenia Caused by Combined Therapy with Atypical Antipsychotics and Niuhuang Ninggong Tablet

目的评估非典型抗精神病药合并牛黄宁宫片导致白细胞减少症的风险性。方法对198例使用1种非典型抗精神病药的精神分裂症患者中白细胞减少症的发生情况,进行回顾性调查,收集人口学、临床诊断、牛黄宁宫片合并治疗史等资料,应用单因素、多因素非条件性logistic回归分析。结果合并牛黄宁宫片治疗组白细胞减少症发生率为39.5%,高于单一用药组的3.8%(P=0.000)。单因素、多因素非条件性logistic回归分析均提示,合并牛黄宁宫片治疗者发生白细胞减少症的风险高于未合并治疗组(分别OR=16.74、15.98,P=0.000)。结论非典型抗精神病药合并牛黄宁宫片治疗可显著增加白细胞减少症的发生风险。

Objective To evaluate the risk on leucocytopenia caused by combined therapy with atypical antipsychotics and Niuhuang Ninggong tablet.Methods One hundred and ninety-eight inpatient with schizophrenia using single atypical antipsychotics were studied retrospectively.Demographic,clinical,Niuhuang Ninggong tablet combined therapy were collected through review of the medical record.The relative risk of in-hospital leucocytopenia in patients with atypical antipsychotics was estimated using univariate and multivariate unconditional logistic regression.Results Compared with the group of atypical antipsychotics only which induced leucocytopenia,the incidence were significant high in the group of Niuhuang Ninggong tablet combined therapy（3.8% VS 39.5%,P=0.000）.Univariate and multivariate unconditional logistic regression analysis respectively promt that the risk of leucocytopenia in the treatment combined with Niuhuang Ninggong tablet was higer than the group without combined therapy（OR=16.74,15.98;P=0.000）.Conclusion Combined therapy with atypical antipsychotics and Niuhuang Ninggong tablet visibly increase the risk of leucocytopenia.