艾司西酞普兰和氯丙咪嗪治疗强迫症的对照研究

Comparative Study of Escitalopram and Clomipramine in the Treatment of Obsessive-compulisive Disorder

目的评价艾司西酞普兰治疗强迫症的临床疗效和不良反应。方法将符合入组标准的强迫症患者分为研究组和对照组,研究组服用艾司西酞普兰,对照组服用氯丙咪嗪,疗程8周,采用Yale-Brown强迫症量表(Y-BOCS)、汉密尔顿抑郁量表(HAMD)、副反应量表(TESS),分别在治疗前、治疗第2、4、6、8周进行评分。结果有效率研究组与对照组相比无统计学差异(χ2=0.40,P>0.05)。HAMD评分无统计学差异,TESS评分显示在各时间点两组评分均有显著性差异。结论艾司西酞普兰治疗强迫症疗效与氯丙咪嗪相似,但不良反应明显低于氯丙咪嗪。

Objective To explore the clinical efficacy and the side effects of escitalopram in the treatment of obsessive-compulsive disorder.Methods The patients who accorded with the criteria of obsessive-compulsive were divided into study group and control group,the patients in study group were administered with escitalopram,and control group treated with clomipramine for 8 weeks,and evalulated with Yale Brown Obsessive Compulsive Scale（Y-BOCS）,Hamilton Depression Scale（HAMD）and Treatment Emergent Symptom Scale（TESS）before treatment and 2,4,6,8 weeks after treatment.Results As far as response rate,there was no statistical difference between the two groups（χ^2=0.40,P〉0.05）as well as HAMD scores,but at each time point,the TESS scores was significant difference between the two groups.Conclusion Escitalopram is as effective as clomipramine,but has less adverse reaction than clomipramine in the treatment of obsessive-compulsive disorder.