摘要
采用反相高效液相色谱法测定10名志愿受试者单剂量口服1000mg赖氨匹林胶囊和500mg阿司匹林肠溶片后,血浆中水杨酸浓度变化情况经3P87非室模型药动学程序处理,结果表明,口服1000mg赖氨匹林胶囊后,在水杨酸计的药时曲线下面积、达峰时间及峰浓度与阿司匹林肠溶片相比均无显著性差异(P>0.05)。说明赖氨匹林胶囊和阿司匹林肠溶片为生物等效制剂。以水杨酸计的相对生物利用度为(102.30±7.46)%。
The Salicylic Acid concentrations in plasma were determined by HPLC method following a single dose of Lysin Aspirin Capsule and Aspirin Enteric Tablet was given respectively to 10 volunteers in a open randomized cross over test. The AUC 0→∞ were (254 66±36 19)mg/L×h and (226 71±30 92) mg/L×h;T max were(3 6±0 66)h and (3 8±0 42)h;C max were(50 59±7 43)mg/L and (42 72±3 68)mg/L for Lysin Aspirin Capsule and Aspirin Enteric Tablet repectively.The results of the pair test showed that there were no significant differences between two formulations in the AUC 0→∞ 、T max and C max .These two formulations were bioequivalent. The relative bioavailability of Lysin Aspirin Capsule was 102.30%.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1999年第2期93-95,共3页
West China Journal of Pharmaceutical Sciences