穿琥宁注射液中DAS-K的含量测定和贮存期的预测

PREDICTION OF THE SHELF LIFE OF 2% CHUANHUNING INJECTION

用恒温加速试验法对２％穿琥宁注射液贮存期进行预测并用紫外分光光度法在２５０ｎｍ处测定脱水穿心莲内酯琥珀酸半酯单钾盐吸光度，预测出室温下穿琥宁注射液贮存期为２．３１年。

The active principle(DAS K)2% Chuanhuning Injection is unstable. The stability of the injection was studied by classical isotermal method.Experimental results indicated that the degradation of DAS K obeys the first order kinetics. The shelf life of the injection is about 28 months at room temperature and the activation energy of the degradation is about 104.8kJ/mol.