摘要
目的研究非胰岛素依赖型糖尿病患者(NIDDM)载脂蛋白(Apo)E2等位基因与肾功能不全及血脂水平的关系。方法采用聚合酶链反应ASO探针杂交技术检测130例NIDDM患者及50名正常人ApoE基因型。其中NIDDM肾功能不全者46例;非肾功能不全者84例。结果肾功能不全患者中10例为ApoE2;28例为ApoE3/3。非肾功能不全患者中尿Alb正常者57例,其中6例为ApoE2,51例为ApoE3/3。肾功能不全组ApoE2的出现频率为13%,明显高于非肾功能不全组(5%)及正常人(5%)(P<005);肾功能不全ApoE2组总胆固醇、甘油三酯水平分别为(57±10)mmol/L及(53±17)mmol/L,明显高于肾功能不全Apo3/3组[分别为(47±12)mmol/L及(25±12)mmol/L],及尿Alb正常Apo3/3[分别为(45±11)mmol/L及(24±12)mmol/L]、ApoE2组[分别为(42±08)mmol/L及(20±11)mmol/L];肾功能不全ApoE2组高密度脂蛋白胆固醇明显低于其它3组。结论ApoE2等位基因与NIDDM肾功能不全有?
Objective To study the relationship of ApoE2 and renal insufficiency, lipid levels in NIDDM patients. Methods PCR/ASO probe technique was used to determine ApoE genotypes. 46 NIDDM patients with renal insufficiency and 84 NIDDM patients without renal insufficiency as well as 50 healthy individuals were selected. Of the patients with renal insufficiency, 10 belonged to ApoE2 and 38 to ApoE3/3. In addition, 57 NIDDM patients with normoalbuminuria (6 with ApoE2,51 with ApoE3/3) were selected from the 84 NIDDM patients without renal insufficiency. Results Allele frequency was significantly higher in diabetic patients with renal insufficiency than in diabetic patients without renal insufficiency and in healthy individuals (P<005). Tc, TG levels were significantly higher in ApoE2 group with renal insufficiency than in E3/3 group with renal insufficiency, ApoE3/3 and ApoE2 groups with normoal buminuria. HDLc level was significantly lower in ApoE2 group with renal insufficiency than in other 3 groups. Conclusion ApoE2 is associated with renal insufficiency in NIDDM patients and that ApoE2 may be a factor that aggravates lipid abnormalities in NIDDM patients with renal insufficiency.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1999年第5期339-342,共4页
National Medical Journal of China
基金
全军"九五"青年科学基金
关键词
糖尿病
NIDDM
等位基因
载脂蛋白
肾功能
polipoproteinAllele geneDiabetes mellitus
noninsulindependentKidney failure