同种骨基质明胶加石膏修复骨缺损的实验研究

THE EXPERIMENTAL STUDY OF REPAIRING BONE DEFECTS WITH ALLOGENEIC BONE MATRIX GELATIN AND PLASTER

目的研究骨基质明胶加石膏复合物在骨缺损修复过程中的作用。方法新西兰兔１６只，桡骨干缺损为植骨区，实验组植入骨基质明胶加石膏复合物（１６侧），对照组分别植入骨基质明胶（８侧）和酒精储存骨（８侧），观察骨缺损的修复情况。结果实验组成骨活跃，１２周时骨缺损已基本修复。对照组也有成骨现象，但进展不如实验组。结论骨基质明胶加石膏复合物为一种良好的骨移植材料。

Objective To study the function of the composite of bone matrix gelatin(BMG)and plaster in the repairing process of bone defects.Methods Sixteen New Zealand rabbits which were defected in corpus radii were made as implant zone of bone.Sixteen sides of radii were implanted with the composite of BMG and plaster as experimental group.Others were implanted with BMG(8 sides)and bone stored in alcohol(8 sides)as control groups. The repairing process in bone defects were observed by X ray and histological examination.Results There was an obvious osteogenesis in experimental group.The defects of radii were almost healed at 12th week after operation.There were osteogenesis in both control groups,but the repairing process was slower than that of the experimental group.Conclusion The composite of BMG and plaster is a good material for bone transplantation.