磁性纳米氧化铁粒子在肿瘤影像及治疗中的应用及进展

Application and progression of magnetic iron oxide nanoparticles for tumor imaging and therapy

磁性纳米氧化铁粒子是指直径在纳米范围的氧化铁粒子，具有化学性质稳定、血液滞留时间长、低毒性、顺磁性、生物可降解性等特点，可通过静电作用或化学作用耦联多肽、单克隆抗体、化疗药物、基因片段等靶肿瘤功能分子，因而在肿瘤影像、治疗、研究中有着广泛的应用。该文对近年来磁性纳米氧化铁粒子在肿瘤影像及治疗中的应用及进展进行了评述。

Magnetic iron oxide nanoparticles are iron oxide particles of nanometer diameter with the characters of steady chemical property, long blood retention time, low toxicity, paramagnetism and biodegradability. Due to the cross-linking to tumor-targeting ligands through electrostatic interaction or chemical coupling such as peptides, monoclonal antibodies, chemotherapeutic drugs, gene segments. They are widely used for clinical oncology imaging, therapy and investigation. This article focuses on the applications and recent developments of magnetic iron oxide nanoparticles for tumor imaging and therapy.