钾锶复合掺杂聚磷酸钙修复兔下颌骨缺损

Repair of mandible defect with kalium and strontium-doped calcium polyphosphate

目的观察钾锶复合掺杂聚磷酸钙(KSCPP)修复兔下颌骨箱状骨缺损的疗效。方法随机将12只健康成年日本大白兔分为A、B组,在其双侧下颌骨下缘中部制备15mm×4mm×2mm的骨缺损,在其右侧缺损区,A组植入KSCPP,B组植入羟磷灰石(HA);两组左侧骨缺损区不植骨,作为空白对照。分别于手术4、8、12周处死试验动物,行X线和组织病理学检查,观察成骨情况。结果所有动物活动正常,进食好;伤口Ⅰ期愈合,无感染。术后12周:KSCPP部分降解且与宿主骨质呈融合状态,大量新骨长入骨缺损区,骨小梁改建为更致密的板层骨,成骨量较B组多;B组HA与骨界面未融合,无成骨现象;空白组骨缺损区为软组织覆盖,未形成骨连接。结论 KSCPP具有优良的生物相容性和可降解性,是一种良好的骨缺损修复材料。KSCPP亦可能具有良好的骨诱导性,但尚需进一步的免疫组化试验给予证实。

Objective To study the effects of kalium and strontium-doped calcium polyphosphate on the repair of mandibular defects of rabbit. Methods Prepare kalium and strontium-doped calcium polyphosphate （KSCPP） and hydroxyapatite （HA）. Bone defects of 15 minx4 mmx2 mm were made at middle part of bottom edge of 12 rabbit mandibles. KSCPP or HA was applied to the right side, while the left side was sutured without implant of materials. After 4, 8, 12 weeks implantation, the effectiveness of bone formation was evaluated by means of X-ray observation and histological examination. Results KSCPP was not rejected by hosts. Mter 12 weeks, KSCPP was partially degraded, newly regenerated bone grew into and merged with the material. The capacity of bone regeneration was stronger than HA. Conclusion KSCPP has a good biocompatibility, osteoconductivity, osteoinductivity, and biodegradation. It may be a promising bone repair alternative.