摘要
目的观察重组人Kunitz型蛋白酶抑制剂的变异体(KD/APP var)对实验性大鼠急性坏死性胰腺炎(acutenecrotizing pancreatitis,ANP)的治疗作用。方法采用牛磺胆酸钠逆行注入大鼠胰胆管内诱导ANP模型,观察重组人KD/APPvar大鼠血清淀粉酶(AMS)、脂肪酶(LPS)影响及胰腺组织病理变化。结果与模型组比较,重组人KD/APP var治疗组可明显降低急性胰腺炎大鼠淀粉酶、脂肪酶的活性,且使胰腺的病理变化减轻。结论重组人KD/APP var早期给药可显著减轻胰腺高分泌状态,对大鼠急性胰腺炎具有治疗作用。
Objective To determine the therapeutic effect of rhKD/APP var on acute necrosis pancreatitis in rats.Methods Acute necrosis pancreatitis was induced by injections of odium taurocholate into the main pancreaticduct of rats.Serum amylase and lipase activities of the rats were assayed and histopathological changes were observed after treatment with rhKD/APP var.Results rhKD/APP var inhibited the serum amylase and lipase activities remarkably and ameliorated the histopathological changes of the pancreas.Conclusion rhKD/APP var can suppress pathogenesis of the acute necrosis pancreatitis in rats.
出处
《实验动物科学》
2010年第5期26-28,共3页
Laboratory Animal Science
基金
吉林大学科学前沿与交叉学科创新项目基金号(421033603432)
