西洛他唑对缺血性卒中患者血小板聚集功能影响

The Effect of cilostazol on platelet aggregation function in patients with Ischemic stroke

目的 探讨西洛他唑常用剂量下,血小板聚集率的变化规律.方法 60例脑梗死患者,每日服用西洛他唑50mg,一天两次,分别于服药前、服药后2周、4周、8周测定血小板最大聚集率及斜率的变化.结果 与服药前相比,西洛他唑用药前和用药后血小板聚集率有显著性下降,而用药后2周、4周、8周比较无明显变化.结论 西洛他唑对缺血性卒中患者血小板聚集有很好的抑制作用.

Objective To investigate the effect of cilostazol at routine doses on platelet aggregation. Methods Cilostazol was taken at dose of 50mg one day in 60 patients with cerebral infarction, twice per day. Measure the maximum platelet aggregation rate and slone changes berore treatment and 2 weeks, 4 weeks, 8 weeks after taking cilostazol respectively. Results Platelet aggregation rate after taking ciiostazol decreases significantly, compared to that before treatment. While the results of 2 weeks, 4 weeks and 8 weeks after taking cilostazol have no signilfficant difierenee. Conclusion Cilostazol has a good inhibition on platelet aggregation in patients with isehemic stroke.