2Halaas JL,Gajiwla KS,Maffei M,et al.Weight redueing efforts of the plasma Proteine neodebythe obesegene [J].Sceience,2005,269: 543-546.
3Piche T, Vandenb os F, Abakar Mahamat A, et al. The severity of liver fibrosis is associated with high leptin levels in chronichepat it is C. J Viral Hepat,2004,11:91-96.
4Crespo J, RiveroM, Fabrega E, et al. Plasma leptin and TNF-alpha levels in chronic hepatitis C patients and their relationship to hepaticfibrosis. Dig Dis Sci, 2002,47:1604.
6Henriksen JH, Hoist J J, Moiler S, et al. Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal[J]. Hepatology, 1999,29:1818.
7Honda H, Ikejima K, HiroseM, et al. Leptin is required for fibrogenic responses induced by thioaceta mide in the murine liver[J]. Hepatology, 2002,36:12.
8Lecler cq IA, Field J, Farell GC. Leptin2 specific mechanisms for impaired liver regenerat ion in ob / ob mice after toxic injury. Gastroenterolgy,2003,124:1451 - 1464.
9Kaimori A, Potter J, Kaimori JY, et al. Transforming growth factor beta induces an epithelial to mesenchymal transition state in mouse hepatocytes in vitro [J].J Biol Chem,2007,282 (30):22089- 22101.
10Herrmann J,Borkham Kamphorst E, Haas U, et al. The expression of CSRP encoding the L IM domain protein CRP is mediated by TGF-beta in smooth muscle and hepatic stellate cells[J]. Biochem Biophys Res Commun, 2006,345(4):1526-1535.
二级参考文献61
1Clement K, Boutin P, Froguel P. Genetics of obesity. Am J Pharmacogenomics 2002; 2:177-187.
2Safadi R, Friedman SL. Hepatic fibrosis--role of hepatic stellate cell activation. MedGenMed 2002; 4- 27.
3Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
4Potter JJ, Womack L, Mezey E, Anania FA. Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 1998; 244:178-182.
5Mattioli B, Straface E, Quaranta MG, Giordani L, Viora M. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Thl priming. J Immunol 2005; 174:6820-6828.
6Lin SY, Wang YY, Sheu WH. Increased serum leptin concentrations correlate with soluble tumour necrosis factor receptor levels in patients with cirrhosis. Clin Endocrinol (Oxf) 2002: 57:805-811.
7Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 2002; 35: 762-771.
8Dooley S, Delvoux B, Lahme B, Mangasser-Stephan K, Gressner AM. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 2000; 31:1094-1106.
9Ikejima K, Takei Y, Honda H, Hirose M, Yoshikawa M, Zhang YJ, Lang T, Fukuda T, Yamashina S, Kitamura T, Sato N. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002; 122:1399-1410.
10Tang M, Potter JJ, Mezey E. Leptin enhances the effect of transforming growth factor beta in increasing type I collagen formation. Biochem Biophys Res Commun 2002; 297:906-911.
4Wu FT,Stefanini MO,Mae Gabhann F. VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease:an in silieo model[J].American Journal of Physiology-Heart and Circulatory Physiology,2010,(06):H2174-H2191.
5Marra F, Bertolani C. Adipokines in liver diseases. Hepatolo- gy,2009,50(3): 957-969.
6Handy JA, Saxena NK, Fu P, et al. Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3). J Cell Biochem,2010,110 (5):1195-1207.
