甘松对心脏腔内电生理影响的研究

Study of intracardiac electrophysiologic effects of nardostachyos chinensis batal

目的 通过观察甘松对人体腔内电生理的影响,探讨甘松抗心律失常的电生理机制.方法 对40例诊断为室上性心动过速的患者（甘松组）进行口服甘松煎剂前、后的电生理检查.并以我们既往已做的35例电生理检查未服用甘松的室上性心动过速的患者作为对照组.从影响窦房结功能、心房电生理相关指标、房室结电生理相关指标方面进行比较分析.结果 甘松可延长心房有效、相对、功能不应期,功能不应期（FRP）：对照组为（256±69）ms、甘松组为（358±76）ms,相对不应期（RRP）：对照组为（287±55）ms、甘松组为（365±74）ms,差异均有统计学意义（P＜0.05或P＜0.01）,延长心室有效不应期（V-ERP）甘松组（264±36）ms较对照组（213±27）ms延长,差异有统计学意义（P＜0.05）.而对窦房结及房室结功能无影响.结论 甘松抗心律失常的电生理机制与延长心脏不应期、降低心脏兴奋性有关.

Objective To investigate the anti-arrhythmias mechanism of nardostachyos chinensis batal by intracardiac electrophysiologic study. Methods Intracardiac electrophysiologic study were performed in 40 supraventricular tachycardia（SVT）patients before and after oral nardostachys chinensis batal administraton,and the results were compared with 35 SVT patients or normal persons without nardostachys chineusis batal intake. Results The atrial effective,relative,functional refractory periods（AERP,ARRP,AFRP）and ventricular ERP（VERP）were significantly longer in nardostachyos chinensis batal administration group than control（AFRP（358 ± 76）ms vs.（256 ±69）ms;ARRP（365 ±74）ms vs.（287 ±55）ms;VERP（264 ± 36）ms vs.（213 ± 27）ms respectively）;but the sinus and atrioventricular node function had no changes. Conclusions The anti-arrhythmia mechanism of nardostachyos chinensis batal were related to the prolonged cardiac refractory periods and the reduced cardiac excitability.