原发性干燥综合征患者抗着丝点抗体与抗SSA抗体表达的临床特点

Clinical study on anticentromere antibody and anti.SSA antibody in patients with Primary Sjogren＇s Syndrome

目的 探讨抗着丝点抗体（ACA）和抗SSA抗体在原发性干燥综合征（PSS）中的临床及实验室特点.方法 对符合PSS诊断标准的患者分类：12例ACA阳性、抗SSA阴性和19例ACA阴性、抗SSA阳性的PSS患者,在年龄、实验室数据、雷诺现象及唇腺活检组织学改变几方面进行比较.结果 ACA阳性、抗SSA阴性的PSS患者平均年龄（68.4±7.9）岁高于ACA阴性、抗SSA阳性的PSS患者[（54.6±16.2）岁]（P＜0.05）;ACA阳性、抗SSA阴性的PSS患者的血清IgG[（17.89±4.08）g/L]低于ACA阴性、抗SSA阳性的PSS 患者[（27.90±6.72）g/L]（P＜0.01）;ACA阳性、抗SSA 阴性的PSS患者白细胞减少发生率低于ACA阴性、抗SSA阳性的PSS患者（8.3%与42.1%,P＜0.05）;ACA阳性、抗SSA阴性的PSS患者肝脏损害发生率明显高于ACA阴性、抗SSA阳性的PSS患者（66.7%与10.5%,P＜0.05）.结论 ACA可以作为PSS的诊断指标,ACA 阳性的PSS患者与经典抗SSA阳性PSS患者在临床几个方面有显著不同.

Objective To investigate the clinical and laboratory characteristics of anticentromere antibody （ACA）and anti-SSA antibody expressions in patients with Primary Sj（o）gren＇s Syndrome （PSS）. Methods Twelve PSS patients with ACA positive but SSA negative（ACA PSS）and 19 PSS patients with SSA positive but ACA negative（SSA PSS）were enrolled into the study and classified into two groups. We compared the age,laboratory data,occurrence of Raynaud＇s phenomenon（RP）,and histological changes in minor labial salivary glands biopsies of the patients from two group. Results The mean age of the ACA PSS group（68.4 ± 7.9）years was significantly higher than that of the SSA PSS（54. 6 ± 16. 2）years group（P 〈 0. 05）. Serum IgG level of ACA PSS group（17. 89 ±4. 08）g/L was close to the normal range,which was significantly lower than that of SSA PSS（27.90 ±6. 72）（P 〈0. 01）. Leukocytopenia was less frequently observed in ACA PSS than in SSA PSS（P 〈 0. 05）,the difference between two groups was statistically significant. We also found more frequent RP in the ACA PSS group than SSA PSS group（P 〈 0. 05）. Conclusions Our data confirm that ACA positive PSS differs from SSA positive PSS at several clinical respects and laboratorial examinations.