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帕金森病神经保护的临床研究进展 被引量：3

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摘要 帕金森病（Parkinson’s disease，PD）是中老年人常见的神经系统变性疾病，其病因和发病机制复杂。目前认为该病是遗传与环境因素共同作用的结果。环境、遗传、年龄老化、细胞功能障碍（氧化应激、线粒体功能缺失、异常蛋白聚集、
作者 任肖玉(综述) 刘振国(审校)
机构地区 上海交通大学医学院附属新华医院神经内科
出处 《中国综合临床》 2010年第11期1227-1229,共3页 Clinical Medicine of China
基金 上海市科委纳米专项基金（0952nm03700） 上海市基础研究重点项目（09JC1411000）
关键词 帕金森病 神经保护
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献11

  • 1Parkinson Study Group CALM Cohort Investigators. Long-term effect of initiating pramipexole vs levodopa in early Parkinson disease [ J]. Arch Neuro1,2009,66 (5) :563-570.
  • 2Palhagen S, Heinonen E, Hagglund J, et al. Selegiline slows the progression of the symptoms of Parkinson disease [ J]. Neurology, 2006,66 ( 8 ) : 1200-1206.
  • 3Olanow CW, Rascol O, Hauser R, et al. A double-blind, delayed- start trial of rasagiline in Parkinson's disease [J]. N Engl J Med, 2009,361 ( 13 ) : 1268-1278.
  • 4Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trim on symptomatic effects of coenzyme Q ( 10 ) in Parkinson disease [ J]. Arch Neurol,2007,64(7) :938-944.
  • 5Olanow CW, Schapira AH, LeWitt PA, et al. TCI-D46 as a neuroprotective drug in Parkinson' s disease: a double-blind, randomised, controlled thai [ J ]. Lancet Neuro1,2006,5 ( 12 ) : 1013- 1020.
  • 6Parkinson Study Group PRECEPT Investigators. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease [ J ]. Neurology,2007,69 ( 15 ) : 1480-1490.
  • 7NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease [ J]. Neurology,2006,66(5 ) :664-671.
  • 8Slevin JT, Gerhardt GA, Smith CD, et al. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor [ J ]. J Neurosurg,2005,102 (2) :216-222.
  • 9Lang AE, Gill S, Patel NK, et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease [ J]. Ann Neurol,2006,59 (3) :459-466.
  • 10Marks WJ Jr, Ostrem JL, Verhagen L, et al. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin ) to patients with idiopathic Parkinson's disease:an open-label, phase I trial [J]. Lancet Neurol,2008,7 (5) :400-408.

同被引文献26

  • 1Hauser RA,Zesiewicz TA.Advances in the pharmacologic management of early Parkinson's disease.Neurolgist,2007,13(3):126.
  • 2Muriel MP,Bemzrd V,Levey AI,et al.Levodopa induences a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson's disease.Ann Neurol,1999,46(1):103-111.
  • 3Schapira AH.Science,medicine and the future:Parkinson's disease.BMJ,1999,318(7179):311-314.
  • 4Dryja TP,O'Neil-Dryja M,Pawelek JM,et al.Demonstration of tyrosinase in the adult bovine uveal tract and retinal pigment epithelium[J].Invest Ophthalmol Vis Sci,1978,17(6):511-514.
  • 5Smith SB,Zhou BK,Orlow SJ.Expression of tyrosinase and the tyrosinase related proteins in the Mitfvit(vitiligo)mouse eye:implications for the function of the microphthalmia transcription factor[J].Exp Eye Res,1998,66(4):403-410.
  • 6Castillo BV Jr,Little CW,del Cerro C,et al.An improved method of isolating fetal human retinal pigment epithelium[J].Curr Eye Res,1995,14(8):677-683.
  • 7Connor B,Kozlowski DA,Unnerstall JR,et al.Glial cell line-derived neurotrophic factor(GDNF)gene delivery protects dopaminergic terminals from degeneration[J].Exp Neurol,2001,169(1):83-95.
  • 8Sun M,Kong L,Wang X,et al.Comparison of the capability of GDNF,BDNF,or both,to protect nigrostriatal neurons in a rat model of Parkinson's disease[J].Brain Res,2005,1052(2):119-129.
  • 9Subramanian T.Cell transplantation for the treatment of Parkinson's disease[J].Semin Neurol,2001,21(1):103-115.
  • 10吴钢,蔡端,邬剑华,马保金,张延龄,李保国,龚佳蕾,肖强.大鼠胰岛与生长因子共微囊提高囊内胰岛存活率[J].复旦学报（医学版）,2008,35(1):107-110. 被引量：1

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中国综合临床
2010年 第11期

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