含有薁类结构的1,4-二氢吡啶衍生物的合成

Synthesis of 1,4-Dihydropyridines Containing Azulenes Moiety

在对甲基苯磺酸作用下,以1-甲酰基薁-3-甲酸甲酯、乙酰乙酸酯、醋酸铵或3-氨基巴豆酸酯为原料,进行三组分一锅法缩合,以较优的收率制备了含有薁类结构的新的1,4-二氢吡啶类衍生物,该反应收率良好、操作简单、条件温和.产物的结构经1H NMR,IR及元素分析等得以证实.

New 1,4-dihydridine derivatives containing azulene moiety were synthesized by three component one-pot condensation of methyl 1-formoylazulene-3-carboxylate,acetoacetic esters and ammonium acetate or alkyl 3-amminocrotonate under p-toluenesulfonic acid as a catalyst.This method provides several advantages such as good yield and simple work-up procedure.All the products were fully characterized by ^1H NMR,IR spectra and elemental analysis.