(E)-5-(2,5-二甲基-4-(丙烯基)苯氧基)-2,2-二甲基戊酸的合成

Synthesis of (E)-5-(2,5-Dimethyl-4-(prop-1-enyl)phenoxy)-2,2-dimethylpentanoic Acid

以吉非罗齐、丙酰氯为起始原料,经付克酰化、还原、脱水三步反应制得了(E)-5-(2,5-二甲基-4-(丙烯基)苯氧基)-2,2-二甲基戊酸,总收率31.8%,目标化合物经1HNMR和13CNMR确证结构。该工艺所用反应试剂和原料价廉易得,操作简便。

With gemfibrozil and propionyl chloride as starting material,（E）-5-（2,5-dimethyl-4-（prop-1-enyl）phenoxy）-2,2-dimethylpentanoic acid,an impurity of gemfibrozil,was synthesized by three-step reactions including acylation,reduction and dehydration.The total yield was 31.8%.The objective compound synthesized had been characterized by 1HNMR and 13CNMR.This improved procedure had several advantages of low consumption,mild condition,convenient operation.