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CXCR4特异性拮抗剂AMD3100对肿瘤细胞生长转移关系的研究进展

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摘要 趋化因子CXCL12即基质细胞衍生因子1（stromal cell derived factor-1,SDF-1）,与其趋化因子受体CXCR4在介导恶性肿瘤的浸润转移中发挥重要作用,可能与恶性肿瘤的发生、发展密切相关,AMD3100作为一种新型的CXCR4特异性拮抗剂,可通过与CXCR4结合而特异性阻断CXCR4与CXCL12结合,而达到对肿瘤转移的抑制作用.
作者 杨旭升(综述) 王乙水(综述) 杨德林(审校)
机构地区 昆明医学院第二附属医院泌尿外科
出处 《国际泌尿系统杂志》 2010年第6期780-784,共5页 International Journal of Urology and Nephrology
关键词 肿瘤 肿瘤转移
分类号 R73 [医药卫生—肿瘤]
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  • 2Kenji Koishi,Reigetsu Yoshikawa,Tohru Tsujimura,Tomoko Hashimoto-Tamaoki,Syoudou Kojima,Hidenori Yanagi,Takehira Yamamura,Yoshinori Fujiwara.Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer[J].World Journal of Gastroenterology,2006,12(47):7585-7590. 被引量：11
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国际泌尿系统杂志
2010年 第6期

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