期刊文献+

IgA肾病的致病机制与治疗进展

原文传递
导出
摘要 IgA肾病(IgA nephropathy,IgAN)是一种在肾小球系膜区存在以JgA为主的颗粒样沉积、临床上以血尿为主要表现的肾小球肾炎。IgAN是最常见的原发型肾小球疾病,它是各年龄段终末期。肾病(ESRD)的重要病因。因此正确的诊断和治疗策略对于降低IgAN进展为ESRD具有重要的意义,但至今还没有一种理想的治疗方法能改变I酣在肾小球系膜区的沉积。本文综述最近发表的一系列关于IgaN致病和治疗的文章,为临床诊断和治疗提供参考。
出处 《国际泌尿系统杂志》 2010年第6期832-836,共5页 International Journal of Urology and Nephrology
关键词 肾小球肾炎 IGA
  • 相关文献

参考文献38

  • 1Ghumra A,Shi J,Mcintosh RS,et al.Structural requirements for the interactionof human IgM and IgA with the human Fcalpha/mu receptor.Eur J Immunol,2009,39:1147-1156.
  • 2Schroeder HW Jr,Cavacini L.Structure and function of immunoglobulins.J Allergy Clin Immunol.2010,125:S41 -52.
  • 3Kaneko,Syuzou,Usui,et al.Renal involvement of monoclonal immunoglobulin deposition disease associated with an unusual monoclonal immunoglobulin A glycan profile.Clinical and Experimental Nephrolo gy,2010,14:389-395.
  • 4Hisano S,Matsushita M,Fujita T,et al.Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis.Am J Kidney Dis,2001,38:1082-1088.
  • 5Monteiro RC,Halbwachs-Mecarelli L,Roque-BarreiraMC,et al.Charge and size of mesangial IgA in IgA nephropathy.Kidney Int,1985 28:666 -671.
  • 6Oortwijn BD,van der Boog PJ,Roos A,et al.A pathogenic role for secretory IgA in IgA nephropathy.Kidney Int.2006,69:1131 -1138.
  • 7Van der Boog PJM,van Kooten C,de Fijter JW.Role of macromolecular IgA in IgA nephropathy.Kidney Int.2006,67:813 -821.
  • 8Sano T,Hiki Y,Kokubo H,et al.Enzymatically deglycosylated human IgAl molecules accumulate and induce inflammatory cell reaction in rat glomeruli.Nephrol Dial Transplant,2002,17:50 -56.
  • 9Novak J,Vu HL,Novak L,et al.Interactions of human mesangial cells with IgA and IgA-containing immune complexes.Kidney Int,2006,62:465-475.
  • 10Van Es L:Pathogenesis of IgA nephropathy.Kidney Int,1992,41:1720-1729.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部