干细胞治疗缺血性心脏病的主要问题

Primary Matters in Stem Cell Therapy for Ischaemic Heart Disease

干细胞治疗是缺血性心脏病治疗的一种新的治疗策略,是心血管疾病治疗研究的前沿。国内外大量研究显示出细胞移植能够修复受损心肌,减少梗死面积,改善心脏功能。但目前细胞治疗仍处于早期阶段,各种问题尚待解决,如种子细胞类型的选择、细胞分化、梗死区细胞存活、最佳移植途径、安全性等问题还需深入探讨。为此,现总结前期干细胞治疗基础及临床研究结果,就目前存在的问题进行阐述。

Stem cell based therapy is a promising strategy for the treatment of ischaemic heart diseases and is an exciting frontier of cardiovascular disease research.Most studies suggest that cell therapy induced infarct repair has reduced the infarct size and improved cardiac function.However,cell therapy is still in its early stages,and questions remain.For example,what is the optimal cell type for the greatest therapeutic potential,for cell differentiation,growth and survival of stem cells in the infarct area？ There are also several major safety concerns that still need to be evaluated.This article summarizes the evidence from preclinical and clinical studies and discusses the remaining questions.