细胞因子与肝脏缺血/再灌注

Cytokines in Liver Ischemia-reperfusion Injury

肝脏的缺血/再灌注(I/R)损伤可发生在许多的临床操作中,如肝脏的外科手术、肝脏移植和循环休克过程中,致使相关并发症发病率及病死率都显著升高。目前许多的研究都认为在肝脏的I/R损伤的病理过程中,涉及到一些细胞因子如肿瘤坏死因子α、白细胞介素12和白细胞介素6等,同时在肝切除和肝移植的手术中也能发现这些细胞因子的表达增多。这些细胞因子参与肝脏I/R损伤的各个阶段,但在其中发挥的作用仍不确定。就此仅对肝脏I/R损伤中相关细胞因子发挥的作用进行综述。

Liver ischemia-reperfusion injury occurs in a number of clinical settings,including liver surgery,transplantation,and circulatory shock,leading to the significantly increased morbidity and mortality from relative complications. Now extensive investigations have implicated that cytokines such as tumour necrosis factor-α（TNF-α） ,interleukin-12（IL-12） and IL-6 contributeto the pathogenesis of ischemia-reperfusion（I/R） injury and an increase in the production of those cytokines is detected following the hepatic resections and organ transplants bypass surgery. Current evidence indicates that these cytokines are involved in each stage of hepatic I/R injury,whereas these cytokines have controversial roles in the process. The purpose of this article is to review the roles of relative cytokines in I/R injury.