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以SDF-1/CXCR4为靶点治疗疾病的研究进展 被引量：3

SDF-1 /CXCR4 as Therapeutic Targets
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摘要 SDF-1/CXCR4是一对重要的趋化因子配体/受体,与肿瘤、免疫缺陷病毒感染、多种炎症等病理状态相关。以SDF-1/CXCR4轴为靶点治疗相关疾病成为人们研究的热点。阻断CXCR4受体可抑制肿瘤细胞的转移及增殖、防护人免疫缺陷病毒感染、减轻炎性反应。现就以SDF-1/CXCR4轴为靶点治疗相关疾病的研究进展予以综述。 SDF-1 /CXCR4 is a pair of very important ligand/receptor,which plays a concernful role in the pathological process of tumour,infection HIV,and inflammation. There has been increasing studies on SDF-1 /CXCR4 as therapeutic target. The studies concluded that the modulation of SDF-1 /CXCR4 axis could restrain the migration and proliferation of tumor,prevent infection of HIV,and alleviate the inflammation.
作者 杨文博 孔佩艳
机构地区 山东潍坊解放军第 重庆第三军医大学新桥医院血液科
出处 《医学综述》 2010年第21期3230-3232,共3页 Medical Recapitulate
关键词 基质细胞衍生因子1 受体CXCR4 靶点 Stromal cell-derived factor-1 Receptor CXCR4 Targets
分类号 R392.1 [医药卫生—免疫学]
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参考文献10

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同被引文献120

  • 1储子彦,陈晓萍,方晶晶.趋化因子SDF-1及受体CXCR4研究进展[J].生物学杂志,2006,23(1):11-13. 被引量：7
  • 2Kanbe K, Takemura T, Takeuchi K. Synovectomy reduces stromal-cell-de- rivedfaetor-1 (SDF-1)which is involved in the destructionof cartilage in os- teoarthritis and rheumatoid arthritis [J]. Bone Joint Surg Br, 2004,86(2): 296-300.
  • 3Grassi F, Cristino S, Toneguzzi S. CX- CL12 chemokine up-regulates bone re-sorption and MMP-9 release byhuman osteoclasts: CXCL12 levels are in- creased in synovial and bone tissue ofrheumatoid arthritis patients [J]. Cell Physiol, 2004,199(2) :244-251.
  • 4Masuda R, Oishi S, Tanahara N. Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-Derived Antagonists [J]. Bioconjug Chem, 2012.
  • 5Juarez J, Bradstock KF, Gottlieb DJ. Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro [J]. Leukemia, 2003,17 (7) : 1294-300.
  • 6Tamamura H, Omagari A, Hiramatsu K. Certification of the critical impor- tance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 in- hibitor, T140, leads to an exploratory performance of its downsizing study [J]. Bioorg Med Chem, 2002, 10(5): 1417-1426.
  • 7Xu Y, Tamamura H, Arakaki R. Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4 [J]. AIDS Res Hum Retroviruses, 1999,15 (5) :419-427.
  • 8Tamamura H, Sugioka M, Odagaki Y, Conformational study of a highly spe- cific CXCR4 inhibitor, T140, disclos- ing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity [J]. Bioorg Med Chem Lett, 2001,11 (3) : 359-362.
  • 9Tamamura H, Omagari A, Oishi S. Pharmacophore identification of a spe- cific CXCR4 inhibitor, T140, leads to development of effective anti - HIV agents with very high selectivity index- es.[J]. Bioorg Med Chem Lett, 2000, 10(23) : 2633-2637.
  • 10Tamamura H, Omagari A, Hiramatsu K, et al. Development of specific CX- CR4 inhibitors possessing high selectiv- ity indexes as well as complete stability in serum based on an anti-HIV peptide T140 [J]. Bioorg Med Chem Lett, 2001,11 (14) : 1897-1902.

引证文献3

二级引证文献7

医学综述
2010年 第21期

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