摘要
目的观察加兰他敏对老年患者手术后认知功能的影响。方法将200例手术治疗的老年患者随机分为两组(各100例),Ⅰ组只接受常规治疗,Ⅱ组在常规治疗的基础上加用加兰他敏。分别观察并记录术前1天和术后第2～9天的认知功能。结果Ⅱ组术后第2、5、7、9天简易精神状态量表测试得分显著高于Ⅰ组,术后认知功能障碍的发生率显著低于Ⅰ组,差异均有统计学意义(P<0.05)。结论围术期口服加兰他敏可有效改善老年患者术后认知功能。
Objective To observe the effects of galantamine on elderly patients with cognitive function after surgery. Methods 200 elderly patients with surgery were randomly divided into two groups （ each 100 cases） ,Ⅰ group only accepted conventional treatment; Ⅱgroup accepted galantamine treatment in addition to conventional therapy. The cognitive function of two groups in 1 day before operation and 2 to 9 days after operation were recorded respectively. Results The scores of mini-mental state examination in Ⅱgroup were significantly higher than that in Ⅰgroup in the 2nd,5th,7th,9th days after operation,while the incidence of postoperative cognitive dysfunction in Ⅱgroup were significantly lower than that in Ⅰgroup . The difference between the two groups was statistically significant（ P 0. 05） . Conclusion Perioperative application of galantamine may improve cognitive function in elderly patients.
出处
《医学综述》
2010年第21期3356-3357,共2页
Medical Recapitulate
关键词
加兰他敏
老年人
术后认知功能
Galantamine
Elderly patients
Postoperative cognitive function
