厄贝沙坦在老年原发性高血压病患者中的应用研究

Study on the Effect of Irbesartan Treatment in Senile Primary Hypertension

目的:探讨厄贝沙坦治疗老年原发性高血压病患者的临床疗效和安全性,以及对左心室肥厚的影响。方法:将80例老年原发性高血压病患者随机分为观察组和对照组各40例,观察组采用厄贝沙坦治疗,对照组采用阿替洛尔治疗,观察比较两组患者用药前和用药后血压、心率、生化检查及临床表现;治疗前及治疗后分别测定患者LVH。结果:服药两组患者血压、心率等均降低,LVH逆转,但是厄贝沙坦效果更好,差异存在显著性(P<0.05)。结论:厄贝沙坦对老年原发性高血压患者有可靠的降压作用,对LVH有显著的改善作用,安全性高,是治疗老年原发性高血压病有效的药物。

Objective： To explore the clinical effect and safety of irbesartan treatment in senile primary hypertension,and the effect on left ventricular hypertrophy（LVH）.Method：80 patients with senile primary hypertension were randomly divided into the intervention group（40 cases） and control group（40 cases）.The intervention group were treated with irbesartan,the control group were treated with atenolol.Then observed and compared BP、HR、blood biochemical examination and clinical phenomena before and after irbesartan treatment,LVH were determined before and after irbesartan treatment.Result：After medication,blood pressure and heart rate decreased of two groups decreased、reversal of LVH;However,the effects of irbesartan were better,there were significant differences（P〈0.05）.Conclusion：Irbesartan treatment in senile primary hypertension has long antihypertensive effect and safety,can improve LVH,it is an effective drug in treating the senile primary hypertension.