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血清胱抑素C在诊断早期糖尿病肾病中的作用 被引量：3

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摘要 目的探讨血清胱抑素C(CystatinC)在诊断早期糖尿病肾病中(DN)的应用价值,比较血清CystatinC与血清肌酐(SCr)、内生肌酐清除率(CCr)和24h微量白蛋白排泄率(UAER)的相关性。方法检测52例糖尿病患者与50名健康对照者的SCr、UAER与血清CystatinC,并计算CCr。结果血清CystatinC与SCr、CCr及UAER均与糖尿病呈显著相关(P<0.01),且血清CystatinC与CCr相关性优于SCr与CCr相关性,并与SCr方向一致,同时还优于UAER与Ccr相关性。结论血清CystatinC对糖尿病患者肾功能损害的早期诊断具有积极意义和临床价值,值得推广。
作者 廖瘳
机构地区 广东药学院附属第一医院内分泌科
出处 《中国现代医生》 2010年第33期163-163,182,共2页 China Modern Doctor
关键词 血清胱抑素C 内生肌酐清除率 糖尿病肾病 早期诊断
分类号 R587.2 [医药卫生—内分泌]
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参考文献3

  • 1Song E,Lee SK,Wang J,et al. RNA interference targeting Fas protects mice ftom fulminant hepatitis[J]. Nat Med, 2003,9(3) : 347-351.
  • 2Anastasi A, Brown MA, Kembhavi AA, et al. Cystatin, a protein inhibitor of cystein proteinases. Improved purification from egg white, characterization, and detection in chicken serum[J]. Biechem J, 1983,211 : 129-138.
  • 3Filler G,Bokenkamp A,HofmannW,et al. Cys C as a marker of GFR-history,indieations,and future research[J]. Clin Biochem,2005,38: 1-8.

同被引文献27

  • 1李玉艳,杨振坤,李强.胱抑素C在临床中的应用进展[J].国际检验医学杂志,2006,27(9):812-813. 被引量：106
  • 2Bokenkamp A,Domanetzki M,Zinck R,et al.Cystatin C-a new marker of glomerular filtration rate in children independent of age and height[J].Pediatrics,1998,101(5):875-881.
  • 3Boonen S,Mohan S,Dequeker J, et al. Down regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, IGFBp-3 and IGFBp-5) in age-related(type II) femoral neck osteoporosis [J]. J of Bone and Miner Res, 1999,14(12) :2150-2158.
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  • 7Rigalleau V, Lasseur C, Raffaitin C,et al. Bone loss in diabetic patients with chronic kidney disease [J] . Diabet Med,2007,24(1) :91-93.
  • 8Bacchetta J, Boutroy S, Vilayphiou N,et al. Early impairment of trabecular microarchitecture assessed with HR-pQCT in patients with stage II-IV chronic kidney disease [J] . J Bone Miner Res, 2010,25(4) :849-857.
  • 9Anastasi A, Brown MA, Kembhavi AA, et al. Cystatin,a protein inhibitor of cystein proteinases. Improved purification from egg white, characterization,and detection in chicken serum [J] . Biochem J,1983,211(1) :129-138.
  • 10Filler G,Bokenkamp A,Hofmann W,et al. Cys C as a marker of GFR-history,indications, and future research [J] . Clin Biochem,2005,38(1) : 1-8.

引证文献3

二级引证文献12

中国现代医生
2010年 第33期

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