心肌肌钙蛋白-Ⅰ在急性脑血管病中对脑-心综合征判断的应用分析

Analysis of cardiac troponin in the diagnosis of brain-heart syndrome in acute cerebrovascular disease

目的：探讨心肌肌钙蛋白-Ⅰ（CTn-Ⅰ）在急性脑血管病中对脑-心综合征判断的应用价值。方法：232例均在12 h内清晨空腹取静脉血,测CTn-Ⅰ、肌酸激酶（CK）及同工酶（CK-MB）、乳酸脱氢酶（LDH）和天门冬氨酸转移酶（AST）,每次24~48 h,共2~9次。结果：CTn-Ⅰ增高者,CK等4项均增高;CK等4项增高者,而CTn-Ⅰ正常。病情重、年龄高和高血压者,CTn-Ⅰ异常发生率高,与预后有一定关系,与病变性质无明显关系。结论：CTn-Ⅰ对脑-心综合征判断更敏感,特异性更强。病情重、年龄高和高血压者,易发生脑-心综合征,与病变性质无明显关系。

Objective：To investigate the value of cardiac troponin（CTn-Ⅰ）in the diagnosis of brain-heart syndrome in acute cerebrovascular disease.Methods：The venous blood of 232 subjects were taken within 12 h after hospitalization,and the levels of CTn-Ⅰ,creatine kinase（CK）,creatine kinase-MB（CK-MB）,lactate dehydrogenase（LDH） and alanine transaminase（AST） were detected repeatedly every 24-48 h for 2-9 times.Results：In these subjects,the results showed if the level of CTn-Ⅰ was increased,the levels of CK,CK-MB,LDH and AST were all increased at the same time.Although in partial subjects,the levels of CK,CK-MB,AST,LDH were increased,but CTn-Ⅰ remained normal.Elderly severe subjects with hypertension often had high occurence for abnormal CTn-Ⅰ,which was related to prognosis,but not associated with characteristic of lesions.Conclusions：CTn-Ⅰ is more sensitive for diagnosis of brain-heart syndrome in contrast to CK,CK-MB,LDH and AST.And elderly severe subjects with hypertension are easy to have brain-heart syndrome,which is not associated with characteristic of lesions.